Publications
Publication highlights
Hexanucleotide repeat expansions in C9orf72 alter microglial responses and prevent a coordinated glial reaction in ALS
Masrori P, Bijnens B, Davie K, Poovathingal SK, Storm A, Hersmus N, Fumagalli L, Van Den Bosch L, Fiers M, Rudolf Thal DR, Mancuso R, Van Damme P
Deep proteomic analysis of human microglia and model systems reveal fundamental biological differences of in vitro and ex vivo cells
Lloyd AF, Martinez-Muriana A, Hou P, Davis E, Mancuso R, Brenes AJ, Geric I, Snellinx A, Craessaerts K, Theys T, Fiers M, De Strooper B, Howden AJM
A multi-pronged human microglia response to Alzheimer’s disease Aβ pathology
Mancuso R, Fattorelli N, Martinez-Muriana A, Davis E, Wolfs L, Van Den Daele J, Geric I, Preman P, Serneels L, Poovathingal S, Balusu S, Verfaille C, Fiers M, De Strooper B.
Stem-cell-derived human microglia transplanted in mouse brain to study human disease
Fattorelli N, Martinez-Muriana A, Wolfs L, Geric I, De Strooper B and Mancuso R
Chen WT, Lu A, Craessaerts K, Pavie B, Sala Frigerio C, Corthout N, Qian X, Laláková J, Kühnemund M, Voytyuk I, Wolfs L, Mancuso R, Salta E, Balusu S, Snellinx A, Munck S, Jurek A, Fernandez Navarro J, Saido TC, Huitinga I, Lundeberg J, Fiers M and De Strooper B
Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition
Pasciuto E, Burton OT, Roca CP, Lagou V, Rajan WD, Theys T, Mancuso R, Tito RY, Kouser L, Callaerts-Vegh Z, Fuente AG, Prezzemolo T, Mascali LG, Brajic A,Whyte CE, Yshii L, Martinez-Muriana A, Naughton M, Young A, Moudra A, Lemaitre P, Poovathingal S, Raes J, De Strooper B, Fitzgerald DC,Dooley J, and Liston A
Stem-cell-derived human microglia transplanted in mouse brain to study human disease
Mancuso R, Van Den Daele J, Fattorelli N, Wolfs L, Balusu S, Burton O, Liston A, Sierksma A, Fourne Y, Poovathingal S, Arranz-Mendiguren A, Sala Frigerio C, Claes C, Serneels L, Theys T, Perry VH, Verfaillie C, Fiers M, De Strooper B.
CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice
Mancuso R, Fryatt G, Cleal M, Obst J, Pipi E, Monzón-Sandoval J, Ribe E, Winchester L, Webber C, Nevado A, Jacobs T, Austin N, Theunis C, Grauwen K, Daniela Ruiz E, Mudher A, Vicente-Rodriguez M, Parker CA, Simmons C, Cash D, Richardson J; NIMA Consortium, Jones DNC, Lovestone S, Gómez-Nicola D, Perry VH.
Early microglial activation precedes neuronal loss and behavioural impairment in mice with a Frontotemporal dementia-causing CHMP2B mutation
Clayton EL*, Mancuso R*, Tolstrup Nielsen T, Mizielinska S, Holmes H, Powell N, Norona F, Overgaard Larsen J, Lythgoe MF, Ourselin S, Nielsen JE, Johannsen P, Holm I, Collinge J, FREjA, Oliver PL, Gomez-Nicola D, Isaacs AM. *Joint first author
CSF1R blockade slows the progression of amyotrophic lateral sclerosis by reducing microgliosis and invasion of macrophages into peripheral nerves
Martinez-Muriana A*, Mancuso R*, Francos-Quijorna I, Olmos-Alonso A, Osta R, Perry VH, Navarro X, Gomez-Nicola D, Lopez-Vales R. *Joint first author
Pharmacological targeting of CSF1R inhibits microglia proliferation and prevents the progression of Alzheimer’s-like pathology
Olmos-Alonso A, Schetterrs ST, Sri S, Askew K, Mancuso R, Vargas-Caballero M, Holscher C, Perry VH, Gomez-Nicola D.